top of page

KEY PUBLICATIONS 

  • Ballal AR, Reddy SK, Chandran D, Hegde S, Upadhya R, Kumar SEP, Shenoy S, Devi V, Upadhya D. Cell-specific extracellular vesicle-encapsulated exogenous GABA controls seizures in epilepsy. Stem Cell Research & Therapy (under revision)

  • Welsh JA, Goberdhan DCI, O'Driscoll L,.et al., Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches. J Extracell Vesicles. 2024 Feb;13(2):e12404.

  • Roy S, Kashyap NN, Anchan AS, Punja D, Jasti DB, Upadhya D. Urinary extracellular vesicle dynamics in Parkinson's disease patients with urinary dysfunction. Front Neurol. 2023;14:1250832.

  • Reddy SK, Ballal AR, Shailaja S, Raviraja NS, Raghu Chandrashekhar RH, Sankhe R, Pai K, Tender T, Mathew M, Aroor A, Shetty AK, Adiga S, Devi V, Manjunath SM, Upadhya D. Small extracellular vesicle-loaded bevacizumab reduces the frequency of intravitreal injection required for diabetic retinopathy. Theranostics. 2023. DOI: 10.7150/thno.78426

  • Upadhya D, Attaluri S, Liu Y, Hattiangady B, Castro OW, B, Shuai B, Dong Y, Zhang SC,  Shetty AK. Grafted Human PSC-derived GABA-ergic Interneurons Directly Regulate seizures  and specific  Cognitive Function in Temporal Lobe Epilepsy. npj Regenerative Medicine 2022; 7(1): 38.

  • Sabitha KR, Divya C, Shetty AK, Upadhya D. Delineating the neuropathology of lysosomal storage diseases using patient-derived induced pluripotent stem cells. Stem Cells and Development. 2022.  31 (9-10), 221-238.

  • Attaluri S, Upadhya R, Kodali M, Madhu LN, Upadhya D, Shuai B, Shetty AK. Brain-Specific Increase in Leukotriene Signaling Accompanies Chronic Neuroinflammation and Cognitive Impairment in a Model of Gulf War Illness. Frontiers in Immunology. 2022 ;13:853000. 

  • Chakraborty A, Hegde S, Praharaj SK, Prabhu K, Patole C, Shetty AK, Mayya SS, Acharya RV, Hande HM, Prabhu MM, Upadhya D. Age Related Prevalence of Mild Cognitive Impairment in Type 2 Diabetes Mellitus Patients in the Indian Population and Association of Serum Lipids With Cognitive Dysfunction. Frontiers in Endocrinology. 2021 Dec 31;12:798652.

  • Deshmukh AS, Praharaj SK, Rai S, Kamath A, Upadhya D. Prefrontal Cortex Transcranial Direct Current Stimulation Treatment in Alcohol Dependence Syndrome (PreCoTTA): Study Protocol for a Double-Blind Randomized Sham-Controlled Trial. Reviews in Recent Clinical Trials. 2021;16(4): 409-420. 

  • Upadhya D, Shetty AK. Promise of extracellular vesicles for diagnosis and treatment of epilepsy. Epilepsy & Behaviour. 2021; 121; 106499.

  • Ni H, Biagini G, Upadhya D, Capuano A. Editorial: Endocrine Modulators of Neurological Processes: Potential Treatment Targets of Pediatric Neurological Diseases. Frontiers in Endocrinology. 2021; 12:655290.

  • Sabitha KR, Shetty AK, Upadhya D. Patient-derived iPSC modeling of rare neurodevelopmental disorders: Molecular pathophysiology and prospective therapies. Neuroscience and Biobehavioral Reviews. 2021; 121: 201-219.

  • Shetty AK, Attaluri S, Kodali M, Shuai B, Shetty GA, Upadhya D, Hattiangady B, Madhu LN, Upadhya R, Bates A, Rao X. Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness. Redox Biology. 2020; 28: 101389.

  • Upadhya D, Kodali M, Gitai D, Castro OW, Zanirati G, Upadhya R, Attaluri S, Mitra E, Shuai B, Hattiangady B, Shetty AK. A model of chronic temporal lobe epilepsy presenting constantly rhythmic and robust spontaneous seizures, co-morbidities and hippocampal neuropathology. Aging and Disease. 2019; 10(5):915-936.

  • Upadhya D, Shetty AK. Extracellular Vesicles as Therapeutics for brain injury and disease. Current Pharmaceutical Design. 2019; 25: 3500–3505.

  • Upadhya D, Hattiangady B, Castro OW, Shuai B, Kodali M, Attaluri S, Bates A, Dong Y, Zhang SC, Prockop DJ, Shetty AK. Human induced pluripotent stem cell- derived MGE cell grafting after status epilepticus attenuates chronic epilepsy and comorbidities via synaptic integration. Proceedings of the National Academy of Sciences U S A. 2019; 116: 287-296.

  • Upadhya D, Castro OW, Upadhya R, Shetty AK. Prospects of Cannabidiol for Easing Status Epilepticus-Induced Epileptogenesis and Related Comorbidities. Molecular Neurobiology. 2018 55: 6956-6964.

  • Castro OW, Upadhya D*, Kodali M, Shetty AK. Resveratrol for Easing Status Epilepticus Induced Brain Injury, Inflammation, Epileptogenesis, and Cognitive and Memory Dysfunction-Are We There Yet? Frontiers in Neurology. 2017; 8: 603 (*equal contribution).

  • Shetty GA, Hattiangady B, Upadhya D, Bates A , Attaluri S, Shuai B, Kodali MK , Shetty AK. Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in Gulf War Illness. Frontiers in Molecular Neuroscience. 2017; 10:182.

  • Long Q*, Upadhya D*, Kim DK, Hattiangady B, An SY, Prockop DJ, Shetty AK. Intranasal MSC-Derived A1-Exosomes Decrease Inflammation and Preserve Neurogenesis in the Hippocampus as well as Prevent Memory Dysfunction after Status Epilepticus. Proceedings of the National Academy of Sciences U S A. 2017; 114(17):E3536-E3545 (*equal contribution)

  • Upadhya D, Hattiangady B, Shetty GA, Zanirati G, Kodali M, Shetty AK. Neural Stem Cell or Human Induced Pluripotent Stem Cell-Derived GABA-ergic Progenitor Cell Grafting in an Animal Model of Chronic Temporal Lobe Epilepsy. Current Protocols in Stem Cell Biology. 2016; 38:2D.7.1-2D.7.47.

  • Shetty AK & Upadhya D. GABA-ergic cell therapy for epilepsy: Advances, limitations and challenges. Neuroscience and Biobehavoral Reviews. 2016; 62:35-47.

  • Zhang J, Upadhya D, Lu L, Reneker LW. Fibroblast growth factor receptor 2 (FGFR2) Is required for corneal epithelial cell proliferation and differentiation during embryonic development. PLoS ONE. 2015;10(1):e0117089.

  • Upadhya D, Ogata M, Reneker LW.  MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development. Development. 2013; 140: 1573-82.

bottom of page